Medical Center District Vacations from $452

Book a Hotel + Flight or Car together to unlock savings

Your Medical Center District Vacation

Experience all the wonderful things this neighborhood has to offer with a tailor-made Medical Center District vacation package. However you picture yourself spending your days here, you'll find countless opportunities for fun, adventure and relaxation. Your trip to Medical Center District wouldn't be complete without a visit to major attractions nearby such as University of Texas Health and Science Center at San Antonio, Huebner Oaks and Wonderland of the Americas Mall. Expedia can help you turn your ideal Medical Center District vacation into reality, whatever your budget or travel plans.

The Latest Medical Center District Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hilton Garden Inn San Antonio Airport South
Hyatt Regency Hill Country Resort and Villas
Mokara Hotel & Spa San Antonio
Hotel Contessa
Sítio El Tropicano

Where to stay in Medical Center District

Find the best Medical Center District areas and neighborhoods for the activities you enjoy most. Learn more about Medical Center District

Medical Center District Hotel Deals

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $106 total per night from Nov 15 to Nov 16
$106 total
Nov 15 - Nov 16
Total with taxes and fees
8.4/10 Very Good! (3,781 reviews)
"Great, clean property, nice environment and people"

Reviewed on Nov 12, 2026

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $112 total per night from Dec 13 to Dec 14
$112 total
Dec 13 - Dec 14
Total with taxes and fees
San Antonio Marriott Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center

3 out of 5
9806 Interstate Hwy 10 W San Antonio TX
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $107 total per night from Nov 22 to Nov 23
$107 total
Nov 22 - Nov 23
Total with taxes and fees
Drury Inn & Suites San Antonio Northwest Medical Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Medical Center District attractions

Things to do

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.